The syphilis has been one of the diseases that has accompanied the human civilization from his origins to the present time. Outlined in Fracastoro's works in the 16th century, his contagious origin it is recognized. From the 20th Century onwards, when the treponema pallidum and the infections mechanisms were discovered, there were established hygienic procedures. It is known that before the introduction of the penicillin, en1944 in the United States of North America, 65 % of the neurological organic patients of the Cook Country Hospital of Chicago were suffering neurosyphilis, the most serious complication of the tertiary Studium. 8 of every 10 patients were suffering worldwide this complication. In Mexico, The Mexican Institute of the Social Security in 1944 had total population registered 22% of the total population seeking medical services and 77 % were suffering neurosiphyíls. In the Mayo Clinic in the USA were resgistered 4 % and 65-78 % they had neurological manifestations. In the General Mental hospital of Mexico City (Manicomio de la Castañeda) existed an special Pavilion that was sheltering this type of patients in his terminal phase. The Mexican government worried by the presence of the syphilis carry out different boardings in order to eradicate it, epidemiological, clinical and legal issues. This work takes as an aim the analysis of the policies of health carried out during the decade of the years 1940 to 1960, fundamental time for the erradication of syphilis in Mexico