A historical and epistemological features on the role played by machines and machineries in the 16th century–during Tartaglia’s time are provided. In order to offer a standpoint regarding the new scientific interest of science at that time for the development of practical science around machines and machineries a compound analyses among foundations of mechanical science, concept of applied science, machines and examples of machineries are presented. Particularly, a) the science recognized as science at that time is briefly reported to be correlated with the knowledge of the non scientist men as builders, architects, engineering. Usually a discussion concerning history of science and technique/technology is presented such as a discipline within the history of science for understanding eventual relationship between science and the development of art crafts produced by non–recognized scientists in a certain historical time.[1] Thus most offer interesting outlooks of analysis within a predominant paradigm–key of investigation Nevertheless, an a priori relationship between science and technique/technology is hypnotized, e.g.: a) Presenting mechanics and mechanism and then the general importance of machines. The study is within science and technique as unique technical paradigm of investigation. b) Presenting philosophy of mechanic–ism to explain traditions, heritage and aims. The study is within philosophy as unique paradigm of investigation. c) Presenting the role played by religions to explain traditions, heritage and aims. The study is within philosophy as unique paradigm of investigation. d) Presenting the rationalism of ancient writings as having remarkable impact on Renaissance scholars. The study is within humanism philosophy as unique paradigm of investigation. On my side a historical–epistemological analysis related with eventual, (how and when) use of science (physics, mathematics and geometry) worked with machines and machineries would be presented. A main question is: when and why the tension between science (physics, mathematics and geometry) gave rise to a new scientific approach to applied discipline such as studies on machines and machineries during 16th centaury The foundations are the main key of investigation of current science at that time, so will start from science at that time to investigate both the role played by theoretical and conceptual frameworks by means of the eventual bridge between science and techniques/technologies within machines and machineries. In that sense what kind of science was (if) used for projecting machines and machineries?