Even many historians of science and medicine endorsed, in the recent past, the widespread belief that the exodus of Central European scientists and physicians during the National Socialist Period could be represented as a purely linear equation of subtractions and additions of intellect. This common interpretation followed a simplistic brain gain model of the exodus of academics, intellectuals and scientists after the Nazi seizure of power, when most notably the U.S. (in North America) and U.K. (in Europe) were enriched through the process of forced migration. Though this view is not entirely wrong, if a rather quantitative meta-perspective is taken, it remains less compelling, though, when the individual biographies of scientists are taken into account and placed in their historically contingent work environments. This presentation introduces some individual, local and cultural factors that implicated the arrival, acceptance and integration of many German-speaking émigrés-doctors and brain researchers, following their exile between 1933 and 1945. When tracing their career paths into the early 1960s, a period, when the scientific research landscapes in Canadian and US-American biomedicine gradually changed, the complex cultural modes, scientific interactions and evolutionary patterns associated with the forced-migration process become obvious. As shall be argued here, the integration of German-speaking émigrés-neuroscientists cannot be perceived simply as a supplementation of long-standing North-American scientific traditions in place, but must be described as a very complex process of acculturation on multiple levels of the social and cultural organization of American and Canadian academic landscapes.